A STUDY of the early hours of multiplication of herpes virus in chick embryo cells1 showed that some 90 per cent of the virus present in the cells at the beginning of incubation could not be detected 3 and 6 hr. later. The method of cell homogenization employed in this work to extract virus for titration left the cell nuclei intact, and the findings of Gray and Scott2 suggested that the virus lost in the early hours of incubation might have made its way into the nuclei, and so escaped detection. This possibility was investigated.
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